The Center for Adaptive Systems of Brain-Body Interactions (CASBBI) was chartered by Mason’s Office of the Provost as part of a university-level initiative for establishing Transdisciplinary Centers of Advanced Study.


To enable individuals with chronic disability to participate in needed and desired life roles and activities.


CASBBI pursues transdisciplinary research to understand and modulate complex adaptive systems underlying human movement and behavior.


Recognizing that chronic disability is characterized by dysfunction in multiple interrelated systems across physical, biological and psychosocial domains, CASBBI brings together experts in neuroscience, physics, engineering, computer science, psychology, and rehabilitation to pursue convergence research.

Our research is motivated by problems of major public health and societal significance, such as chronic pain, substance misuse and addiction, autism spectrum disorders, and mobility impairments. Our goal is to develop improved interventions and outcomes for these conditions.

Accomplishing this goal involves the integration of knowledge across disciplines to uncover underlying neurobiological mechanisms of disability, to modulate them through novel technological approaches, and to develop measurement tools sensitive to changes resulting from the interventions.


The expected outcomes of CASBBI are to:

  1. Build research capacity by student training and development
  2. Conduct paradigm-shifting research at disciplinary interfaces
  3. Develop open-source tools, data repositories, and platforms
  4. Impact society by creating economic value and improved human health outcomes